Syllabus Section- Science and technology


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Pune-based Serum Institute of India (SII) unveiled India’s first indigenously developed pneumococcal vaccine on Monday. The world’s largest vaccine manufacturer by doses, SII is also the maker of Covishield, the Indian version of the AstraZeneca-Oxford coronavirus vaccine.


• SII’s pneumococcal vaccine, Pneumosil, was developed through a collaboration spanning over a decade with the health organisation PATH and the Bill and Melinda Gates Foundation.He said the Serum Institute’s vaccines are used in 170 countries and every third child in the world is immunised with one of its vaccines.

• The vaccine targets the pneumococcal bacterium, which causes pneumonia and other serious life-threatening diseases such as meningitis and sepsis, and is estimated tocause nearly four lakh deaths in children under five years of age each year worldwide.


• Pneumococcal disease is a significant contributor under-five mortality rate worldwide. In view of its widespread fatality, the World Health Organization in 2018 recommended the inclusion of the pneumococcal conjugate vaccine (PCV) in routine childhood immunisation programmes in all countries.

• Serum’s first indigenous PCV will be available in the market at an affordable price in single dose (vial and prefilled syringe) and multidose (vial) presentations. While PCVs have helped reduce pneumococcal deaths, they are difficult for many countries to afford. The unique feature of the WHO pre-qualified PCV is its composition which is specially tailored to the serotype of the bacterium, S penumoniae, in India and other regions of the world.

• Pneumosil has been extensively evaluated in five randomised controlled clinical trials and has demonstrated comparable safety and immunogenicity against licensed pneumococcal vaccines across diverse populations of India and Africa, where Pneumosil was administered to adults, toddlers and infants using different vaccination schedules, officials said. Based on the trials, Pneumosil was licensed by the Drugs Controller General (India) in July 2020.

• The vaccine also makes SII the world’s third supplier of PCVs under the pneumococcal Advance Market Commitment, and the first developing country vaccine manufacturer to access the global PCV market.




Source- Indian Express

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