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NEWS IMPULSE – What is mRNA vaccine | 17 NOVEMBER

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><b><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”>Syllabus Section: Science and Technology</span></span></span></b></span></span></span></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><b><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”>Context:</span></span></span></b></span></span></span></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”>The Moderna and Pfizer&nbsp; both announced results of human trials of the vaccines it has developed with US National Institutes of Health related to Corona virus.The Moderna and Pfizer vaccines use the same technology, based on messenger RNA, or mRNA.</span></span></span></span></span></span></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><b><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”>What is mRNA?</span></span></span></b></span></span></span></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”>Messenger ribonucleic acids (mRNAs) transfer the information from DNA to the cell machinery that makes proteins.Ribosomes read the mRNA and translate the message into functional proteins in a process called translation. In other words messenger RNA molecules tell the body&rsquo;s cells what proteins to build.</span></span></span></span></span></span></p>

<p style=”text-align:center”><img alt=”” src=”https://i.filecdn.in/476edenias/freesnippingtool-com_capture_20201117132856-1605600024614.png” /></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><b><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”>mRNA-1273 is a </span></span></span></b></span></span></span></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”>novellipid nanoparticle (LNP)-encapsulated mRNA-based vaccinethat encodes for a full-length, prefusion stabilized spike (S) protein of SARS-CoV-2.</span></span></span></span></span></span></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><b><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”>Benefits:</span></span></span></b></span></span></span></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”> A coronavirus vaccine bas</span></span></span><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”>ed on mRNA, once injected into the body, will instruct the body&rsquo;s cells to create copies of the spike protein. In turn, this is expected to prompt the immune cells to create antibodies to fight it.</span></span></span></span></span></span></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”> These antibodies will remain in the blood and fight the </span></span></span><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”>real virus if and when it infects the human body.</span></span></span></span></span></span></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><b><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”>Risks Associated:</span></span></span></b></span></span></span></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”> These are completely new and revolutionary vaccines, it will know virtually nothing about their long-term effects.</span></span></span></span></span></span></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”> Risk related to bio-distribution and persistence of the induced immun</span></span></span><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”>ogen expression; possible development of auto-reactive antibodies; and toxic effects of any non-native nucleotides and delivery system components.</span></span></span></span></span></span></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”> mRNA is so fragile, the Pfizer vaccine must be stored at negative 70 degrees Celsius. If the ideal environm</span></span></span><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”>ent is not maintained, the vaccine could &ldquo;spoil&rdquo; and become ineffective.</span></span></span></span></span></span></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”> It would be the worst [scenario] if people behave like they are immune but can still become infected.</span></span></span></span></span></span></p>

<p style=”margin-bottom:13px”><span style=”font-size:11pt”><span style=”line-height:115%”><span style=”font-family:Calibri,sans-serif”><b><span style=”font-size:12.0pt”><span style=”line-height:115%”><span style=”font-family:&quot;Cambria&quot;,&quot;serif&quot;”>Source : Indian Express</span></span></span></b></span></span></span></p>

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